wholesale kratom is scientifically known as Mitragyna Speciosa. Kratom (Mitragyna speciosa) is a tropical evergreen tree from Southeast Asia and is local to Thailand, Malaysia, Indonesia and Papua New Guinea. Intrahepatic Cholestasis Following Abuse of Powdered Kratom (Mitragyna speciosa). Davidson L, Rawat M, Stojanovski S, Chandrasekharan P. Natural drugs, not so natural effects: Neonatal abstinence syndrome secondary to 'kratom'.

Mitragyinine and 7-OH are two of kratom's primary alkaloids that have known mu-opioid receptor (MOR) agonist activity.4,5 This means they stimulate the mu opioid receptor in a similar fashion to other full agonists at the MOR such as morphine and heroin and provide euphoric and analgesic properties.

In the case of mitragynine, whole cell assay research shows binding to mu‐opioid receptors without recruitment of beta‐arrestin 2, which is linked to many adverse effects associated with classical opioids, such as respiratory depression, euphoria and tolerance development 8 The available scientific evidence indicates that the kratom indole alkaloids mitragynine and 7‐hydroxymitragynine are not functionally identical to opioids; their molecular and pharmacodynamic mechanisms of action are distinctly different.

A lot of short and long-term users claimed to have felt an increase in their capability for hard work, activeness, and heightened sexual desire 13 , 15 An anonymous cross-sectional online survey was conducted in the USA in 2006, where 8049 users were studied through available social media and online resources from the American Kratom Association 16 This study concluded that kratom is primarily used by middle-aged (31-50 years) and middle-income ($35,000 and above) individuals, the main purposes being to treat pain (68%) and emotional or mental conditions (66%).

And Kratom leaves are known to help in easing both the types of pain. Kratom is usually sold as cried, powdered leaves, but it's also available as extracts. Red Dragon Kratom is becoming increasingly known for having similar effects with Caffeine. At the higher, sedative dose ranges, kratom users report a diminished sensitivity to physical and emotional pain, and a feeling of general contentedness.

Jansen KL, Prast CJ. Ethnopharmacology of kratom and the Mitragyna alkaloids. Kratom powder has analgesic nature and has a strong pain-killing effect on the body. As a passionate biologist in recovery myself and that has some direct experience with kratom, I hope this piece offers deeper insight into Mitragyna Speciosa and its role in addiction.

The energy provided by kratom is reported to dramatically increase focus by many users, given the right strain. The Food and Drug Administration has warned the public about the health risks of kratom use. The green vein strains are more subtle than the red or white veins.